Applications of Microdialysis in Pharmaceutical Science
by Tung-Hu Tsai
English | ISBN: 0470409282 | 2011 | 584 pages | PDF | 13,2 MB
Discover new and emerging applications for microdialysis in drug evaluation
Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces.
This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research.
starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include:
Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases
Continuous measurement of glucose concentrations in diabetics
Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs
Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs
Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution
Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring
Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.
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