Nicola J. Camp, Angela Cox - Quantitative Trait Loci: Methods and Protocols
Published: 2002-04-26 | ISBN: 0896039277, 1617372544 | PDF | 360 pages | 3 MB | English
Statistical methods for the analysis of quantitative trait locus (QTL), in conjunction with genome-wide screening technologies, are today yielding exciting results in the study of human disease, experimental organisms, and agriculture. In , Drs. Nicola Camp and Angela Cox have asseMB | Englishled a highly experienced panel of statistical geneticists who demonstrate in a step-by-step fashion how to use this powerful methodology and associated software for the detection and fine mapping of quantitative trait loci. Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and useful variations and/or extensions to standard methods are included that ease the reader toward understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov chain Monte Carlo method for joint linkage and segregation analysis.
Up-to-date and highly practical, makes available to nonmathematical investigators a step-by-step guide to the productive use today of all the latest techniques for localizing genes involved in complex quantitative traits.
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